Ole Gunnar Solskjaer has named a strong team to face Sheffield, as United will be aiming for a win to go back top of the league.
The likes of Tuanzebe, Telles and Greenwood would get an opportunity in the starting line up.
Seen the lineup below
United: De Gea; Wan-Bissaka, Tuanzebe, Maguire (c), Telles; Matic, Pogba; Greenwood, Fernandes, Rashford; Martial.
Subs: Henderson, Lindelof, Shaw, Fred, James, Mata, McTominay, van de Beek, Cavani.
Sheffield United: Ramsdale, Basham, Jagielka, Ampadu, Baldock, Lundstram, Norwood, Fleck, Bryan, McGoldrick, Sharp.
Subs: Foderingham, Lowe, Bogle, Mousset, Brewster, Burke.