Manchester United striker Anthony Martial is unavailable for the game against Chelsea as he serves the second of his three-match suspension this weekend.
Brandon Williams, Marcos Rojo and Facundo Pellistri are all unavailable after playing for the Under-23s on Friday night against Everton.
Deadline day signing Edinson Cavani could make his Manchester United debut against Chelsea, with the Uruguayan forward part of the provisional squad for the Chelsea game.
Confirmed United squad members for the game against Chelsea
David de Gea, Dean Henderson, Nathan Bishop, Aaron Wan-Bissaka, Timothy Fosu-Mensah, Victor Lindelof, Harry Maguire, Axel Tuanzebe, Luke Shaw, Alex Telles, Donny van de Beek, Nemanja Matic, Scott McTominay, Fred, Paul Pogba, Juan Mata, Bruno Fernandes, Daniel James, Mason Greenwood, Edinson Cavani, Marcus Rashford, Odion Ighalo