Manchester United boss Jose Mourinho has made some changes to the team that lost 3-1 at West Ham on Saturday.
David De Gea as expected starts for Manchester United while captain Antonio Valencia, Eric Bailly, and Alexis Sanchez return to the starting XI.
Marcus Rashford, who scored in the defeat to West Ham from the bench, also starts against Valencia.
Here are the lineups:
Man Utd XI: De Gea, Valencia, Smalling, Bailly, Shaw, Fellaini, Matic, Pogba, Rashford, Lukaku, Sanchez.
Subs: Romero, Darmian, Lindelof, Fred, Mata, McTominay, Martial
Valencia XI: Neto, Gabriel, Kondogbia, Goncalo Guedes, Parejo, Gaya, Coquelin, Rodrigo, Piccini, Batshuayi, Garay.
Subs: Domenech, Ruben, Vezo, Soler, Gameiro, Cheryshev, Diakhaby, Wass.