Manchester United will be hoping to return to winning ways against West Ham after the goalless draw against Wolves at Old Trafford last weekend and the Carabao Cup loss to Derby on Tuesday.
Alexis Sanchez fails to make the squad for the game against West Ham and Scott McTominay starts.
Here are the lineups:
Manchester United XI: De Gea, Young (c), Smalling, Lindelof, Shaw, Fellaini, Matic, McTominay, Pogba, Martial, Lukaku.
Subs: Grant, Bailly, Darmian, Ander Herrera, Fred, Mata, Rashford
West Ham: Fabianski, Zabaleta, Balbuena, Diop, Masuaku, Rice, Noble (C), Obiang, Yarmolenko, Arnautovic, Anderson.
Subs: Adrian, Ogbonna, Fredericks, Perez, Antonio, Diangana.